PRP institutes an autologous and highly concentrated solution of plasma, which is prepared from the patient’s own blood and contains a concentrated source of growth factors.
After creating platelet-rich plasma from a patient’s blood sample, that solution is injected into the target area. In some cases, the clinician may use ultrasound to guide the injection. The idea is to increase the concentration of specific bioproteins or hormones, called growth factors, in a specific area to accelerate the healing process.
3 cases of women were examined, each of them experiencing premature menopause of POF. Ages were 34, 41 and 41 and all of them had rejected oocyte donation, and opted for intraovarian injection of autologous platelet-rich plasma (PRP) with the aim to rejuvenate the ovarian tissue and enable the employment of their own gametes through IVF. Weeks following the autologous platelet-rich plasma treatment, there was a significant reduction in the patient’s FSH levels.
First case was a 34 year old woman who experienced early menopause at age of 31, with absence of menstruation for 10 months. The patient had also reported 2 years of failing to achieve a natural conception, and the couple was diagnosed with unexplained infertility. For starters, FSH was recorded at 142 mIU/mL , LH mIU/mL and estradiol was 5 pg/mL and AMH was 0.8 ng. Restoration of the menstrual cycle was reported 3 weeks following PRP application. The recorded FSH levels were 9 mIU/mL and the AMH levels were 0,8ng/mL. Employing a natural cycle and natural conception was decided. Five months later, no conception was achieved and FSH returned at 60 mIU/mL. It was then decided to perform another PRP treatment. After three months, the FSH levels were 8.9 mIU/mL and both doctor and patient decided to proceed with IVF. The patient was subjected to an oocyte collection three months after PRP administration, and following the embryo transfer, a biochemical pregnancy ensued and was confirmed by a positive human chorionic gonadotropin (hCG) level of 102 mIU/mL.
Second case was a 41 year old woman, diagnosed with POF at the age of 37. She had already performed 3 IVF cycles with PGS. The recorded FSH levels before the PRP treatment wERE 22 mIU/mL and AMH was 0,06ng/ml. Employing a natural cycle , not including the use of stimulation drugs or the use of an antagonist, the patient has subjected to an ultrasound and hormonal levels control every month, 30 days after PRP treatment FSH was 13.9 mIU/mL and AMH 0.30 ng/ml. Two months after FSH was 12.5 mIU/mL and AMH 0,20ng/ml. After three months naturally conceived pregnancy occurred.
Third case was a 41 year old, with low AMH, perimenopausal and with 6 miscarriages in the past years due to abnormal chromosomal aneuploidies. Twenty days after PRP treatment in the second day of the menstrual cycle the FSH level was 9 mIU/mL and AMH 0,23 ng/ml. In the second month after the PRP treatment a natural conceive pregnancy was established. Harmony test was performed at 10 weeks of pregnancy with no result of aneuploidy.
Read more about the study here.
179 women that underwent intra-ovarian platelet-rich plasma (PRP) injection over the last five years, were studied and analyzed. Women were over the age of 35 with at least one ovary with a history of infertility, hormonal abnormalities, absence of menstrual cycle and/or POF. Average age of them was 43 years old and both FSH levels and E2 significantly reduced after treatment from 29.0 pg/ml to 18.0 pg/m, and from 65.6 pg/ml to 47.2 pg/ml respectively. None of the 179 women reported any complications post operatively, and after PRP, 17 of the total number became pregnant.
The results of the study revealed that PRP intra-οvarian injection is associated with improved function of ovarian tissue, but further clinical trials should be performed in order to shed extra light to the ovarian rejuvenation therapy treatment.
Read more about the study here.
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