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Dr. Fraidakis Mattheos
dr fraidakis, crete fertility centre

Dr. Fraidakis Mattheos

Obstetrics and Gynaecology
Expertise: Assisted Reproduction
Active: Since 1984
Languages Spoken  English, Italian, French, German, Greek


Crete Fertility Centre established 30 years ago, has been offering personalized services to infertile couples, using state-of-the-art technology and psychological support. The result is the birth of 6000 babies all over the world with the contribution of our unit.
Its peaceful location permits the provision of sensitive attention for each couple’s individual needs and specific medical circumstances in their quest for parenthood.
The international level, state of the art facilities, ensure that the highest quality of care is available. Medical and laboratory equipment is the most modern currently available, while standards of hygiene, health and safety are exemplary, in full compliance with the highest and strictest levels in Europe. These have already been confirmed by ISO Certification procedure, having the respective specification by the 24th of February of 2010. Moreover, since November 8th 2017, it is one of the few clinics in Europe that has the DIN EN 15224 certification, which is the European framework for standards for the development and implementation of healthcare management systems.
It is noteworthy that Crete Fertility Centre is located on the seafront in one of the biggest and & most beautiful islands in the Mediterranean, Crete. Thus, it is not surprising that couples travelling to this familiar holiday destination find that the tranquil setting on this beautiful island, lessens the inevitable anxiety and tension of imminent fertility treatment.
Add to this, our cost effective pricing policy (compared to other European and countries worldwide) and the highest standards of medical expertise, science and health, establish Crete Fertility Centre as the best choice for cost, effectiveness and safety for all ART needs.

Academic Career

Dr. Fraidakis graduated from the “LA SAPIENZA” Medical Faculty of Rome’s University (Italy) in 1983. In 1984, he trained at the B’ Surgery Clinic of Athens General Military Hospital. He undertook his specialty at the Academic Unit of Obstetrics and Gynaecology at the Royal London Hospital, training in the principles of assisted reproduction, endoscopic surgery, and diagnosis/treatment utilizing Colposcopy & Laser, supervised by the Head of the Unit, Professor J.G.Grudzinskas, a doctor of world-class reputation in the field of assisted reproduction. In 1990, he completed his specialty training at the Obstetrics-Gynaecology clinic of Athens University (Aretaeon Hospital, Athens) under Clinic Director P.A Zourlas, where he was awarded a Ph.D. with Honours of the Medical School of Athens University. Title of his Ph.D. thesis: “PLASMA AND AMNIOTIC FLUID CONCENTRATIONS OF FIBRONECTIN DURING NORMAL AND POST TERM PREGNANCY”. Afterward, Dr. Fraidakis joined the medical team at Bridge Fertility Centre, one of the largest centers of assisted reproductive technology in the UK, at London Bridge Hospital while, at the same time, he was appointed as a clinical fellow and assistant researcher in the Academic Unit of Obstetrics-Gynaecology and Reproduction physiology, directed by Professor J.G.Grudzinskas, at the Royal London Hospital. In 1992, he also acted as visiting lecturer to the Academic Unit at the Royal London Hospital in Assisted Reproductive Technology and endoscopic surgery.

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Professional Experience

Since 1992, Dr. Fraidakis is the Clinical and Scientific Director of the IVF Unit, “Crete Fertility Centre” in Heraklion, Crete, Greece, where he has had the privilege of successfully offering quality services in assisted reproduction to the highest clinical and scientific standards while never losing focus of the specific needs of couples who have sought care at Crete Fertility Centre. Dr. Fraidakis has significant research work, formatting advanced methods of daily clinical practice. His research activity is a result of his clinical experience. Moreover, the processing of Crete Fertility Centre’s statistical data has led to the formation of studies, some of which have been published, while others are either in publicatio mode or in completion mode. He has published many innovative surveys in well known international scientific magazines and conferences which contribute in the improvement of pharmaceutical protocols and the precaution of severe complications such as the ovarian rejuvenation in In Vitro Fertilisation – IVF. Dr Fraidakis’ knowledge and experience have a significant positive impact in consulting couples with infertility problems, resulting in the birth of healthy children. His research and clinical work is extended with collaborations with national and international institutes and universities in the field of research -clinical protocols. The collaboration with University of Aarhus, Denmark and, specifically, with Prof. Claus Yding Andersen, has results of great importance for women who face cancer. Crete Fertility Centre is the first one which applies the method of ovarian tissue freezing for women who face cancer. The achievement of this method is not only the freezing procedure but also the fact that the tissue is fully functional after the thaw process, producing ovums. This method has been applied to many women who face cancer, making them able to live the dream of motherhood. Dr. Fraidakis has a continuous scientific and clinical collaboration with Professor J.G. Grudzinskas, leading doctor in human assisted reproduction, aiming in the confrontation of complex and of unknown cause cases of human assisted reproduction. Simultaneously, he participates in the team of ovarian rejuvenation, an issue that affects thousands of women with high FSH and in several cases with amenorrhea. Dr. Fraidakis is in cooperation with the Department of Biology of the University of Crete and FORTH institute aiming in perfecting laboratory techniques for the prompt and of high guarantee estimation of the quality of embryos before the process of embryo transfer. Crete Fertility Centre already applies these techniques resulting in the raise in pregnancy rates. Moreover, Dr Fraidakis is in close cooperation with the fertility clinic “Versys Clinics – Human Reproduction Institute” directed by MD, MA Attila Vereczkey, chair of Hungarian Human Reproduction Society, providing consulting services for the Pre-implantation Genetic Diagnosis (PGD) technique.

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He has published original papers in Greek and International scientific journals. Also, he has made a personal presentation of others at International and National conferences. He is regularly an invited speaker and chairman at scientific National and International congresses and seminars, as well as an organizer of conferences that concern infertility ART and prevention of severe complications in IVF. His clinical activities range from 5000 births of healthy children all over the world, following successful IVF programs, to successful reproductive surgery operations, hysteroscopic and laparoscopic operations, and impregnation of people with special requirements. His research activity stems from his extensive clinical experience in combination with the processing of statistical data of “Crete Fertility Centre” leading to International published results. The intention is to create studies, some of them have been published, while others are going to press and others are at various stages of completion.

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Dr. Fraidakis is a distinguished member of: European Society of Human Reproduction and Embryology(E.S.H.R.E.) American Society for Reproduction Medicine (A.S.R.M.) European Society of Gynaecological Endoscopy (E.S.G.E.) Greek Society of Fertility & Infertility Greek Society of Gynaecological Endoscopy Greek Society of Obstetrics & Gynecology

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Egg Freezing

Egg freezing, also known as mature oocyte cryopreservation, is the method used to save women’s ability to get pregnant in the future.


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Ovarian Rejuvenation Therapy

Pregnancy rates achieved in the clinic -after PRP– are 48%, of which 26% was achieved with natural conception.

Ovarian PRP Rejuvenation is a two-step procedure.

  • The 1st one is the preparation of your PRP, it takes less than an hour and it separates the white blood cells and platelets from the red blood cells and serum.
  • The 2nd step is to inject the PRP into the ovaries. The key difference in Crete’s approach is that they use a non-surgical approach to ovarian injections. An approach less invasive, safer, and with a shorter, more comfortable recovery.

To increase the efficiency of the PRP, Crete Fertility Centre started to apply a novel technology by enriching and fortifying that with growth factors (EnPRP), derived from the own patient’s blood.

The most important benefit of the EnPRP : it contains a higher concentration of growth factors, and that offers extra energy to the ovarian rejuvenation process.

Ideal candidates for Ovarian PRP are:

  • menopausal/perimenopausal women under 50 years old
  • infertile women over 35 years with low egg reserve and low AMH
  • women under the age of 35 with low egg reserve and low AMH
  • women with POF

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Egg Donation

Success rates: 52-54% per E.T.

Egg donation is indicated for women who, for various reasons, do not produce eggs.

Some of the donors from the clinic can be Egg-sharers. ‘Egg-sharing’ is an option offered to women who would not otherwise be able to afford the expenses of the fertility treatment they need. In exchange for sharing (or donating) some of the eggs they produce during their own IVF Cycle, the Egg-sharer receives subsidised treatment.

Clinic’s priority is to ensure that patients requiring treatment using donor eggs receive this treatment within a reasonable timeframe (1-3 months).

They can also provide patients with information about:

  • the build
  • height and weight
  • eye and hair color
  • occupation and education
  • blood type of the donor.

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ICSI (Intracytoplasmic Sperm Injection)

Pregnancy rates of Crete Fertility Centre –performing it: ~48 – 50%

ICSI, is a micromanipulation technique developed to help achieve fertilization for couples with severe male factor infertility or couples who have had failure to fertilize in a previous IVF attempt.

The technique involves:

  • picking up a single live sperm
  • injecting it directly into the center of a human egg.

Pregnancy rates are comparable to those seen with IVF in couples with no male factor infertility.


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Crete’s overall pregnancy rates: ~60.2%.

4 steps IVF procedure:

  • Stimulation of the ovary to produce several fertilizable oocytes.
  • When follicular maturation is judged to be adequate, hCG is given and this causes ovulation 42 hours after the injection. Then around 10 to 15 eggs are retrieved and the procedure takes about 20 minutes and is usually done under conscious sedation or general anesthesia.
  • Fertilization of the eggs and semen in the laboratory.
  • Placement of the embryos into the uterus for implantation.

In Greece 3 embryos are usually transferred and 4 embryos to women older than 40 years.

Cases when IVF is the ideal option:

  • Absent fallopian tubes or tubal disease
  • Endometriosis
  • Male infertility
  • Genetic diseases that result in miscarriage or abnormal births.

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Medical Center Address
Heraklion, Crete, Greece

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Medical Center Address
Heraklion, Crete, Greece

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Dr. Fraidakis Mattheos
Obstetrics and Gynaecology