In the last 4 years, Dr. Garavelas has been performing Ovarian Rejuvenation PRP at the Institute of Life IASO Maternity Hospital with much success!
The hospital’s performance is mentioned below:
1,200 PRP Ovarian Rejuvenation treatments through transvaginal guided ultrasound with an overall response rate of over 72%.
300 PRP Ovarian Rejuvenation with Laparoscopic Technique with an overall response rate of over 72%.
PRP therapy response rate is over 72% with more than 90% of patients having a significant improvement of ovarian function.
A 40% pregnancy rate has been achieved in the group of responding patients.
Dr. Garavelas has contributed immensely to this achievement, performing the following Ovarian PRP Techniques:
PRP FORTE II®
Not all PRP is created equal!
PRP products differ both qualitatively & quantitatively.
It is well documented that not all PRP is the same, such as PRP FORTE II® performed by Dr. Garavelas.
What is PRP FORTE II®?
PRP FORTE II ® offers all of the good and none of the bad. PRP FORTE II ® is a platelet-rich plasma preparation that contains highly concentrated platelet growth factors with reduced red blood cells. PRP FORTE II ®, concentrated from your own blood, contains healing factors such as white blood cells, growth factors and stem cell signaling markers. These cells are vital for tissue regeneration and repair. Platelets once thought of being responsible for only clotting, have been scientifically proven to be a reservoir of these vital healing components. With advanced techniques, we are able to concentrate these regenerative healing cells in a simple outpatient setting.
Is it safe?
PRP FORTE II® is from your own blood, autologous, so there is little to no risk when conducted by a trained professional. Since the cells are autologous there is no risk for an allergic or immune reaction. Side effects or complications with PRP FORTE II ® are extremely rare.
How is the procedure for ovarian rejuvenation performed with PRP FORTE II®?
A small amount of peripheral blood is taken from the patient and placed into an FDA medically approved container. This sterile disposable container is placed in a specialized centrifuge, for spinning twice, to separate the whole blood sample into ‘layers’ of platelet-rich plasma (PRP) and red blood cells. The PRP FORTE II ® layer is aspirated from the red blood cells and is injected or applied, under sterile conditions, into the localized area of abnormality.
PRP FORTE II ® VS traditional PRP
PRP FORTE II® has an advantage over traditional PRP in that it requires a two-step concentration process that eliminates red blood cells (RBCs) and neutrophils. RBCs, which show no therapeutic effects for regeneration, may create a more viscous solution which can be more painful when injected. Neutrophils, a type of white blood cell, have inflammatory components that may increase pain and inflammation post-treatment.
Deliverable platelets are the actual volume of viable platelets contained in a PRP sample. PRP FORTE II ® provides upwards of 9 to 20 billion platelets in a 7mL sample (significantly higher than its closest competitor). High volumes of deliverable platelets enhance the volumetric activity of platelet growth factors and cytokines. Platelet alpha granules contain various platelet growth factors that can promote tissue repair along with platelet cytokines that can provide the chemical stimulus needed to attract and direct regenerative cells to injured tissue. Deliverable platelets are significant in low application volumes.
The total process can last up to 30 minutes. However, the majority of time will be used for processing by a trained medical specialist.
The healing process
PRP FORTE II ® signals for Stem cells and regenerative cells to repair and rebuild the damaged tissue. This accelerated healing process reduces pain, promotes increased strength, and improves overall function. The process, called the healing cascade, can be active and take place over a 4-6-week period.
Long term outcome
Patients can expect to see significant improvement in symptoms over the course of healing time. Patients usually report a gradual improvement in symptoms and return of function. Many patients require two to three treatments to obtain optimal results and may even experience a dramatic return of function and relief within 2-3 months.
LAPAROSCOPIC OVARIAN PRP
Cost: 2,950.00€ (including the contribution of an anesthesiologist).
Until recently, patients with early menopause or low ovarian reserve were destined to lay. Ovarian injection of PRP gave hope to patients and changed the landscape in the medical community. Remember that the classic PRP method uses the patients’ blood, which is centrifuged and the growth factors are isolated from it. So this growth factor cocktail through the needle used in the intake is injected into the ovaries and brings sufficient ovulation to the ovarian tissue for a short time. This method has had relatively good results.
However, this method can potentially have higher success rates if personalized.
It is likely that due to the intravascular injection method by ultrasound monitoring, PRP is not always able to reach the ovarian over layer and some may end up in the abdomen.
In the below cases we recommend laparoscopic PRP:
- Where the ovaries are atrophic (early menopause) and therefore are very small
- When the ovaries are out of position (referring to cases of patients with a history of endometriosis).
The laparoscopic method of ovarian regeneration is even safer and has the best possible results. The idea behind this method is that the ovary is initially prepared and exposed with appropriate incisions, which allow the PRP to accurately reach the ovarian circulation. The incisions cause local activation of growth factors that prepare the ground for the PRP receptor. This treatment is performed under general anesthesia, staying in the hospital for one day with the possibility of the patient being discharged the same night.
Therefore, to test whether the procedure has regenerated new ovaries in the ovaries, AMH (ant allergic hormone), FSH, LH and estradiol levels will be monitored at monthly doses in women who do not have a menstrual cycle and during of menstrual flow in women for a period of three months.
If AMH levels rise, while FSH, LH and estradiol levels decrease, objective evidence of ovarian renewal has been established. Blood tests can be monitored either at our clinic or at any microbiological laboratory in your area. Participants are required in each case to report any change in the menstrual cycle or to recover spontaneously in the event of menopause.
In addition, any indication of pregnancy should be reported to the doctor immediately. For women residing in remote areas or residing abroad, Dr. Garavelas will provide advice on care and in general follow-up at all stages, even during impending pregnancy.
It is important to remember that any therapeutic effect of growth factors may require three (3) to six (6) months of follow-up, as any type of issue transformation will not be immediately apparent. Even if you have ovarian renewal, pregnancy may not be possible, as there may be other factors that could affect physical conception. Also if there is evidence of ovarian renewal, the tubal depth should be confirmed and then the male partner should be reassessed by a semen test as well as a postoperative examination.
This method has been used for the last 6 months with particularly good results, achieving so far 7 pregnancies!
If you are interested in PRP with Dr. Garavelas and you would like to find out which one is the most appropriate treatment for you, fill out this form and MEDIPASS will do the rest!