PRP FORTE II 4th Generation – and Granulocyte Colony Stimulating Factor (GCSF) mobilized Plasma and ASCOT
At Garavelas Medical Group, we understand how upsetting it can be to learn that you do not have enough eggs to conceive naturally. This could be due to early menopause, advanced maternal age or a low ovarian reserve (egg supply). In the past, egg donation was the only way to experience the joys of pregnancy and parenthood, but we now have another option. It is PRP FORTE II 4th generation, for ovarian rejuvenation and Granulocyte Colony-Stimulating Factor (G-CSF). This combination is for increased reproductive potentiality in patients who are poor responders. Tissue regeneration has been achieved in aged mice by young blood administration. Moreover, optimization of ovarian reserve biomarkers has been correlated with the presence of stem cell secreted factors in plasma from poor responder women (PR), undergoing autologous stem cell ovarian transplant, after granulocyte colony-stimulating factor (GCSF) mobilization.
The success of treatment in assisted reproductive technique (ART) cycles depends on the perfect synchrony between embryonic development and endometrial receptivity. The implantation process requires endometrial growth and differentiation of endometrial stromal cells. Human endometrium contains growth factors, receptors for growth factors, cytokines, and other key factors for correct embryonic and endometrial development. Multiple embryos fail to implant, and a relevant percentage of IVF/ICSI treatment failures are due to endometrial receptivity disorders. The granulocyte colony-stimulating factor (G-CSF) and Platelet-rich Plasma (PRP) are among these new therapeutic approaches for recurrent implantation failure and in patients who are poor responders.
WHAT IS PRP FORTE II 4th Generation ®?
PRP FORTE II 4th generation ® is prepared from fresh whole blood and contains several growth factors and cytokines, including vascular endothelial growth factor transforming growth factor, platelet-
derived growth factor and epidermal growth factor Therefore, it will rejuvenate the ovaries, and help regulate endometrial cell migration, attachment, proliferation, and differentiation, resulting in beneficial effects on endometrial receptivity.
WHAT IS G-CSF?
G-CSF is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream associated with cell proliferation and differentiation, produced by reproductive tissue cells. It also promotes endometrial immunomodulation and optimizes the interaction between the embryo and the endometrium. Studies have shown that its use is associated with higher pregnancy rates and lower miscarriage rates.
FOR WHOM IS OVARIAN REJUVENATION SUITABLE
Any woman who is in good physical health and falls into one or more of the following patient categories
PRP was prepared using autologous fresh whole blood and a double-spin method. In brief, a small amount of peripheral blood is taken from the patient and placed into an FDA-medically approved container. This sterile disposable container is placed in a specialized centrifuge, for spinning twice, to separate the whole blood sample into ‘layers’ of platelet-rich plasma (PRP) and red blood cells. The PRP FORTE II 4th generation ® layer is aspirated from the red blood cells and is injected or applied, under sterile conditions, into the localized area of abnormality. Granulocyte Colony Stimulating Factor (G-CSF) is a glycoprotein growth factor that was originally identified as a product of activated T-lymphocytes. Its primary function is to act on bone marrow cells via surface receptors and cause their growth and development. It is also produced by the fallopian tube and uterine cells and G-CSF receptors have been identified on the surface of egg cells. The procedure takes less than an hour, and you receive sedation
medication to keep you relaxed and comfortable. Following your treatment and a brief period of recovery, you can go home to rest. Patients can expect to see significant improvement in symptoms throughout healing time. Patients usually report a gradual improvement in symptoms and return of function. Many patients require two to three treatments to obtain optimal results and may even experience a dramatic return of function and relief within 2-3 months.
THE HEALING PROCESS FORTASC
FORTASC signals for stem cells and regenerative cells to repair and rebuild the damaged tissue. This accelerated healing process reduces pain, promotes increased strength, and improves overall function. The process called the healing cascade, can be active and take place over a 4-6 weeks period.
FOLLOW-UP AFTER OVARIAN REJUVENATION
Following the procedure, Follicle Stimulating Hormone (FSH), Estradiol (E2), Luteinizing Hormone (LH) and AMH levels are measured at monthly intervals in women who do not menstruate and during the menstrual flow in menstruating women for six months. If AMH levels increase, while FSH, LH, and estradiol levels become lower, there is evidence of objective evidence of ovarian rejuvenation. As a result, ovarian rejuvenation with FORTASC may be an option for patients with a low chance of success, depletion of ovary reserves, and advanced age, who have tried several times before but could not develop follicles.
COST OF OVARIAN REJUVENATION THERAPY
The cost of ovarian rejuvenation via PRP / FORTASC application is 2,350.00 € for both ovaries. With this treatment can be done and uterine line rejuvenation. The total cost includes the preparation of PRP, the injections G-CSF procedure, the operative room facility where the intra-ovarian injection is performed with the patient under mild sedation, anesthesiologist’s fee, anaesthesia medication cost and nursing
service fee.
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