Ovarian reserve is determined at birth and continually decreases both in quantity and in quality until it completely runs out during menopause in women usually aged around 45 to 50 years old. However, around 1% of women, for multiple different reasons, experience premature depletion of their eggs, leading to a total or partial end to ovarian function before they age of 40. This is known as premature ovarian failure (POF) or premature ovarian insufficiency (POI).
In these patients, the ovaries stop producing follicles that can be fertilized and, even though in some cases women have spontaneous ovulation cycles, there are no tests to help indicate whether this might happen and, if so, when.
In these cases, ovarian stimulation treatment is not effective and the only other fertility treatments as options are egg or embryo donation.
An that’s where the PRP treatment process begins!
The platelet-rich plasma (PRP) procedure involves drawing blood from patients with a special syringe, which is then left to be centrifuged at the appropriate number of revolutions over a period of time to separate plasma-rich growth factors.
The whole blood will be processed using the separation system. Separation of PRP from low- platelet plasma is performed in a closed system – in a fully automated machine designed for this purpose.
At Institute of Life (IOLIFE), the laboratory makes the optimal concentration and involves the application of complex technology, which uses special separators and systems, divides and filters certain cells, prepares them and activates the growth factors in them. At the end of this procedure, the doctors receive the active plasma containing a large amount of growth factors, including PDGF, TGF-β, VEGF, EGF, and others.
The above method had and still has good results and high success rates.
However, all patients do not respond the same way to the treatment and seems that PRP does not manage to reach the ovarian stroma because some of them may have atrophic ovaries and are in premature menopause, and others may have small ovaries or endometriosis.
That is why, Dr. Grigorakis prefers to perform laparoscopic PRP for optimum results. The doctor uses a camera to view the uterus and inject Platelet-Rich Plasma (PRP) into the ovarian tissue to promote follicle growth. Before the surgery -for example a day before- woman must be tested in order to see if there are any medical problems and prior to the procedure, she must not eat or drink anything for a period of 8 hours, since an anesthetic is used. On the day of the procedure her blood will be drawn for the preparation of the PRP.
This type of ovarian rejuvenation is one of the best ways to maximize health, strong eggs in the ovaries and restore the cycle. Laparoscopic PRP, being a surgical procedure, involves a small incision, requires general anesthesia and longer operating hours but is a very safe process without any risk or side effects for women.
Indications for ovarian activation:
All patients having PRP are advised to undertake certain medical exams following the procedure -at a monthly basis-, to assess the response of the ovarian function rejuvenation to the treatment.
The exams include a blood test to check the level of: Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estradiol (E2) and Anti-mullerian Hormone (AMH). Those exams should be done on the second or third day of the period or if there is no period any day of the beginning month.
The benefit of this procedure is the possibility of achieving pregnancy using the patient’s own eggs, which had not been possible or very unlikely prior to it.
The cost of Laparoscopic ovarian rejuvenation via PRP revolution application is 3,000.00 Euros, and the cost of Transvaginal PRP is 1,700.00 Euros.
The total cost includes the preparation of PRP, the injection procedure, the operative room facility where intra-ovarian injection is performed with the patient under general sedation, anesthesiologist’s fee, anesthesia medication cost and nursing service fee.
For any inquiry do not hesitate to contact us.
If you want to learn more about ovarian rejuvenation in Greece, click here.
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