Crete Fertility Centre
Dr. Fraidakis Mattheos

Infertility treatment

Crete Fertility Centre, established 26 years ago, has been offering personalized services to infertile couples, using state-of-the-art technology and psychological support. The result is the birth of 5000 babies all over the world with the contribution of our unit.
Its peaceful location permits the provision of sensitive attention for each couple’s individual needs and specific medical circumstances in their quest for parenthood.
The international level, state of the art facilities, ensure that the highest quality of care is available. Medical and laboratory equipment are the most modern currently available, while standards of hygiene, health and safety are exemplary, in full compliance with the highest and strictest levels in Europe. These have already been confirmed by ISO Certification procedure, having the respective specification by the 24th of February of 2010. Moreover, since November 8th 2017, it is one of the few clinics in Europe that has the DIN EN 15224 certification, which is the European framework for standards for the development and implementation of healthcare management systems.
It is noteworthy that Crete Fertility Centre is located on the seafront in one of the biggest and & most beautiful islands in the Mediterranean, Crete. Thus, it is not surprising that couples travelling to this familiar holiday destination find that the tranquil setting on this beautiful island, lessens the inevitable anxiety and tension of imminent fertility treatment.
Add to this, our cost effective pricing policy (compared to other European and countries worldwide) and the highest standards of medical expertise, science and health, establishes Crete Fertility Centre as the best choice for cost, effectiveness and safety for all ART needs.

Ovarian Rejuvenation Therapy provided by Crete Fertility Centre

Turn back the fertility clock for women who have experienced early menopause.

Stem Cells can, under the proper biological stimulus, morph into any type of cell in the human body, including eggs. The presence of Stem Cells in the ovaries and their transformation into mature oocytes (egg cells) has been demonstrated in mice by Harvard researchers. Stem Cells have also been shown to be present in the human ovary, so it is quite possible that they can be transformed into eggs by Growth Factors contained in the individuals’ own white blood cells and platelets which have been injected into the ovary.
Injections of Growth Factors, when used for many other types of medical treatments, are made from a patient’s own blood and blood cells and is called PRP (Platelet Rich Plasma) or PDGF (Platelet Derived Growth Factors)Therapy

Crete Fertility center has performed Ovarian Rejuvenation therapy in over 400 women which most of them coming to us from abroad. Up until today, 42 women achieved pregnancy, including one pregnancy of  monozygotic twins, a number that is continuously rising according to the messages  from around the world.

You can read our latest research on Ovarian PRP

What are growth factors, how do they work and are they safe?

Growth Factors are produced naturally by certain blood cells (platelets and white blood cells) when the body is injured, in order to naturally repair the body’s tissues. Remember in your childhood, “skinning” your knee and seeing a thick yellow substance form over the injured area? That was actually a combination of platelets, white blood cells, blood clotting and growth factors that stop the bleeding, prevent infection, and eventually cause the formation of new skin, blood vessels, connective tissues and nerves to replace those which were lost as a result of the injury.
PRP injections have been used clinically for many years by physicians for the treatment of soft and connective tissue injuries, as well as in bone grafts. Many professional athletes use this therapy to accelerate the healing of their sports related injuries. PRP’s are also used in burn patients to help skin grafts to non-surgical facelifts. Of course there are research studies that both confirm and deny the efficacy of PRP therapy in its many and varied medical uses. One thing about PRP therapy that has not been challenged is its safety. Since it is made from a person’s own blood, there can be no transmission of blood borne viruses such as Hepatitis or HIV, as has been reported with use of products made from the blood of other individuals. Moreover, since there are no synthetic chemicals involved and PRP therapy is made from the patients’ own blood products; the possibility of an allergic reaction is extremely unlikely.

How is the ovarian PRP rejuvenation procedure performed?

The process of ovarian PRP rejuvenation involves two steps. The first is the preparation of your PRP. This begins with at the insertion of a needle into your vein in order to obtain several tubes of your blood. Your white blood cells and platelets are separated from the red blood cells and serum by a procedure called centrifugation. The preparation of your PRP takes less than one hour. The next part of the ovarian PRP rejuvenation process is the injection of the PRP into the ovaries. The major difference in our study and the technique described in the referenced case study is that we use a non-surgical approach to the ovarian injections. The technique that we have developed to inject the cells into the ovaries is a nonsurgical, transvaginal ultrasound- guided injection performed under sedation with an anesthetic agent called Propofol. This is basically the same as the procedure that is used for an egg retrieval in the In Vitro Fertilization. In our experience, our approach is less invasive, safer, and has a shorter, more comfortable recovery. We have performed thousands of IVF egg retrieval procedures in the last 25 years, which, in our experience, has a well-established safety record, with an extremely low complication rate.

What are the potential risks and benefits of the procedure?

The benefit of this procedure is the possibility of achieving pregnancy with one’s own eggs, which had not been possible prior to this procedure. Since this is an innovative medical treatment, it must be understood that there is no guarantee, stated or implied, that pregnancy, either naturally, or as a result of any subsequent fertility procedure, will occur. The risks of this procedure are minimal, and are basically the same as those for an egg retrieval procedure, which is part of the In Vitro Fertilization process. The possible side effects are pain after the procedure, which usually resolves in 1-2 hours with pain medication, fever or internal bleeding.
Although complications are rare, they may possibly result in hospitalization.

Crete Fertility Centre recommends that premenopausal women undertaking Ovarian Rejuvenation treatment will benefit greatly if they also perform Vaginal Rejuvenation. It improves significantly the loss of desire, sexual dysfunction and performance or urine incontinence.

Who are candidates for this procedure?

Any woman who is in good physical health and falls into one or more of the four patient categories:

  • Menopausal or perimenopausal women under the age of 50 years.
  • Infertile women, over the age of 35 years, having low egg reserve and low AntiMullerian Hormone levels.
  • Women under the age of 35 years, who have low egg reserve and low AntiMullerian Hormone levels.
  • Women with premature ovarian failure (POF).

How is the ovarian PRP regeneration procedure performed?

In women who do not get periods, the procedure can be performed at any time. In women who do get periods, either regularly or irregularly, the procedure is best performed during the menstrual period or early in the cycle, prior to the development of an egg follicle. The procedure can be performed as early as the day of the initial evaluation.
In order to monitor if the procedure has regenerated new eggs in your ovaries, AMH (antiMullerian hormone), FSH,LH and Estradiol levels are measured at monthly intervals in women who do not menstruate, and during the menstrual flow in menstruating women for a period of six months. If the AMH levels rise, while the FSH,LH, and estradiol levels become lower, there is objective evidence of ovarian rejuvenation is demonstrated.
Even if ovarian rejuvenation is observed, pregnancy may not necessarily occur, since there may be other factors that could interfere with natural conception.
“The researchers need to do some more work to make sure that the resulting eggs are OK,” says Adam Balen at a British Fertility Centre. PRP has also positive effect to women who seek fertility treatment which have an uterus that embryos find difficult to attach to – whether due to cysts, scarring from miscarriages or having a thin uterine lining.
The result reported in this study needs to carry out randomised trials for further investigation. It gives hope that ovarian PRP rejuvenation will prove to be a therapeutic option for women who have age related infertility. The treatment uses the patient’s own blood cells, so there are no foreign blood products or synthetic drugs injected, which could provoke allergic reactions or other side effects.


In vitro fertilization-IVF
Egg Donation
Ovarian Rejuvenation Therapy
Intra-Cytoplasmic Sperm Injection (ICSI)

More Info

Dr. Fraidakis Mattheos

Location Description
56, Arch. Makariou & Sof. Venizelou Str., Heraklion, Crete, Greece
Languages Spoken
English, Italian, French, German, Greek



Patient rated the doctor

I wish you all, at crete fertilitycenter, a very merry Christmas and a happy new year!
I am so grateful being pregnant with two little babyboys. It is going so well, i have no complications, and they are growing so well, both of them. I am having a c-section the 11/2-15 and I hope everything will be all right until then.

We will stay in touch

Big hug and kiss


Patient rated the doctor

Just to let you know that i got home safely and am now taking it easy waiting to do the pregnancy test. We understand that you had our best intentions at heart on Saturday and thank you for your concern. I was very impressed with the staff and the clinic in Crete, everyone was very helpful, professional yet very kind at the same time.

We hope to have a positive outcome.

Many thanks.


Patient rated the doctor

I am so happy to tell you, that my twinboys was born wednesday the 11th February. They are big and healthy and were 3420 and 3310 gr. And 53 and 54 cm long. I cannot take my eyes away from them, they are so lovely, i am so grateful being mother again, with your help. Thank you so very much for my little miracles.

Big hug and kiss


Patient rated the doctor

I hope that this email finds you well. We have heard much about the issues facing Greece and have thought of all of you often. All is good here in Australia. Our gorgeous boy, Flynn, is now a little over 1 year old and walking. I’ve attached a recent photo of him -isn’t he beautiful?
We would love Flynn to have a sibling and are considering coming back to the clinic for another chance.

Kind Regards


Patient rated the doctor

I hope to see you on the weekend for the last injection, but just in case i don’t, i want to say a very big THANK YOU !!
You have been consulting me for many months, answering all my questions, providing guidance and information, making all the arrangements, you are a true gem, the professional conductor and a spiritual psychologist. The mountain, i thought i had to climb you made it into a small hit. When I had my moment of paranoia you were very reassuring and sincere to me. Again, I am very sorry for any distress I caused. I do feel badly, I am not sure why my mind thought this way.
I am very grateful to everyone at the clinic., YOU, Chrissa and Dr. Fraidakis. I felt very comfortable with all of you and i did not find it difficult at all with the procedures. It was a seamless and efficient process and protocol.
I will be writing a excellent review of the clinic to help other women like me find a team of caring professionals, that provide cost efficient fertility opportunities on a beautiful, historic island.
Dr. Fraidakis, is truly wonderful, gifted and brilliant, he is full of talent/expertise and is touching and enhancing so many lives by providing opportunities and hope when sometimes we are at the end of our options.
Chrissa is also a professional who was very helpful in getting me set up for the procedures and for assisting me with my medications and follow-up instructions. She has a very kind soul!

A big thank you to all !

Best wishes, and with lots of love and gratitude.

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